, then the solid needs to be dispersed in a solvent or a reaction liquid to form a slurry, in the feed system,
An external drive field is usually required and the corresponding dispersion effect depends on the size, density and concentration of the particles. Corning reactor pair
For the treatment of solids below 200 microns, the solid content of 10% or less is not problematic.
Hydrogenation reaction case
Catalytic hydrogenation is a common reaction in organic chemistry. Many hydrogenation reactions require harsh reaction conditions (high temperature, high pressure).
And the heat is intense, the reaction is difficult to control. With the improvement of environmental assessment and environmental protection requirements, many traditional processes are in urgent need of upgrading.
Look for safer and more efficient production technology. Today we take the double bond reduction and nitro reduction as an example to introduce the microchannel anti
The application of the reactor in a gas - liquid - solid heterogeneous reaction.
A. Double bond reduction reaction
Reaction Example 1: The product has a reactive group, and the product is easily over-reduced to produce impurities. The chemoselectivity of the kettle reaction
About 80% , and in the microchannel reactor, the selectivity is above 95% , and the reaction time can be quite short.
Reaction Example 2: The reaction was carried out at a high temperature, and the product was easily polymerized to produce a large amount of polymerization impurities. For the kettle reaction,
The polymerization-like impurities are as high as 15% or more; for the Corning microchannel reactor, the polymerization impurities can be controlled within 3% .
B. Nitrobenzene reduction reaction
In the case of achieving the same yield of 98% , in the microchannel reactor, the reaction time can be greatly increased by using a higher reaction temperature.
Shortening, the amount of active catalyst is greatly reduced, and the impurity content is not increased.
C. Flowchart Example of Multiphase Hydrogenation Reaction Realized in Corning Reactor:
D. The process of microchannel reaction process optimization is as follows
The whole process is carried out under anaerobic conditions, and hydrogen can be added or distributed at a time, and the reaction can be quenched instantaneously;
The solid powder catalyst can be prepared into a suspension slurry in a storage tank and transported into the reactor using a diaphragm pump;
A back pressure valve is added at the material outlet to increase and adjust the pressure of the reactor system, and a gas-liquid separator is connected for gas-liquid separation.
From this case, it can be seen that the Corning reactor is treated in a strong exothermic catalytic hydrogenation reaction involving solid catalysts, compared to the kettle.
The concentration of the reaction reactant is increased from 35% to 45% , the temperature is 30° , the temperature is increased to 140° , and the catalyst dosage is reduced by 75% .
The reaction time was shortened from 10 hours to 90 seconds. The reaction process was very smooth and no blockage was observed.
Corning France, China, and India have achieved very good yield results for many hydrogenation reactions:
Example 1 : The selectivity was greatly increased, and the occurrence of side reactions was controlled to make subsequent processing of the product easier.
Example 2 : The conversion rate was greatly improved, the amount of catalyst was reduced, and the cost of raw materials was saved.
Example 3 : Compared to conventional reactors, Corning microchannel reactors have low liquid holding capacity, greatly reducing the risk of reaction.
Second, the solid produced during the reaction
The situation in which solids are produced during the reaction is complicated. Depending on the situation, we can take different approaches.
One of the coping strategies: the kettle process and the microreactor process conditions have relatively large differences, and the kettle reaction is mass transfer.
And the limitation of heat transfer, the reaction temperature and concentration are limited, and the reaction can only be controlled by prolonging the reaction time. and
The microreactor has a strong mass transfer and heat transfer function, and the reaction time is greatly shortened by strengthening the temperature. Increase in temperature
The solubility of the substance has a certain influence, and the product during the reaction may not precipitate a solid. 
The second strategy: the micro-reactor has good mass transfer and short reaction residence time, which can well control the selectivity of the reaction. for
The solids in some reactions are well controlled because of the side reactions.
Coping strategy 3: The reaction product is indeed a solid, and it can be investigated whether the solid can be added during the reaction process.
A certain solvent is extracted to dissolve it. For example, a certain salt is formed, and water is introduced into the middle or the rear portion of the reactor to dissolve it.
Coping strategy 4: The reaction product is indeed a solid case, we must carefully study the shape of the solid, the size of the particle,
The amount produced and the fluidity of the fluid determine whether a microchannel reactor is suitable for use.
Corning Reactor Technology
Corning integrated continuous flow chemical synthesis platform, high degree of automation, rapid screening of process conditions, reaction results
I know. A powerful compound library can be built in a short time and can be seamlessly scaled up to industrial production, in laboratory conditions
Small batch production.
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