Release date: 2017-08-21

Recently, a study led by the University of Wisconsin-Milwaukee (UWM) created a new history of 3D films. The researchers created a special 3D film that documented the virus's preparation to attack healthy cells.

The study was conducted by Brenda Hogue, a professor of virology at Arizona State University, and Andrew Aquila and his colleagues at the Stanford Linear Accelerator Center (SLAC). The study was published on August 14th in Nature's Biological Methods.

This research is of great significance to help us understand the principles of various biochemical processes in cells. In this way, we can better treat a variety of viral diseases.

The decisive technological breakthrough in making this film was attributed to the physicist at the University of Wisconsin-Milwaukee (UWM). By combining concepts in machine learning, differential geometry, graph theory, and diffraction physics, they develop a new generation of algorithms that can process many confusing data and reconstruct an ordered set of images from it.

Researchers need not only the latest technology, but also the world's top equipment. The X-ray free electron laser device (XFEL) is the world's brightest and fastest capturing camera. Using an XFEL from the Stanford Linear Accelerator Center (SLAC), an international team of researchers collected "photographs" of millions of individual viruses in different unknown morphological locations.

The reason for using this device instead of a normal camera is that most viruses are too small to be photographed under normal lighting. The intense X-rays produced by XEFL (using diffraction) can produce particle "images" of nanoscale resolution. When the X-ray hits the particle, the pattern produced by the ray scattering can be further processed as data.

Abbas Ourmazd, a well-known professor from the University of Wisconsin-Milwaukee (UWM), said: "In past studies, scientists had to guess the changes in the process by observing the images of the initial and final states of the molecular biochemical process. In the past, we could not Know exactly what happened in the middle from the beginning to the end. But this new study allows us to observe the process of working with various organisms."

When the virus replicates itself, it invades healthy cells and releases its own DNA into the cells in order to hold the cell body to produce a replica of the virus. Next, a large number of newly generated viruses will leave the cells and infect other cells in the same way.

After analyzing the experimental 3D film, the researchers found that when the virus infects the cells, it rearranges the genome and creates a tubular structure that discharges the DNA into the cells.

“This study provides a new way to understand how the virus changes during the infection phase,” Hogue said.

After the discovery, researchers at the University of Wisconsin-Milwaukee (UWM) learned from the film that chromosome rearrangement and tubular structure generation are not separate events, but part of a series of simultaneous coordination processes.

About five years ago, Ahmad Hosseinizadeh, a senior researcher at the University of Wisconsin-Milwaukee (UWM) (also the first author of the study), began an algorithmic study that could convert XFEL's extremely noisy images into 3D images. “In the past, people didn’t believe that this technology could be implemented,” said Peter Schwander, an associate professor at the University of Wisconsin-Milwaukee (UWM). He believes that technology development will continue to progress through cooperation with scientists in other fields.

Schwander said: "Since 2009, we have started to develop algorithms that correctly sequence images, which gives the University of Wisconsin-Milwaukee (UWM) research team more advantages, but the research process is very difficult. We observe these images by The acquisition process and the concept of data science were used to develop this algorithm."

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"Now showing: Researchers create first 3-D movie of virus in action"

Source: DeepTech Deep Technology (micro signal mit-tr)

Baby Monitor Security Camera

The performance of the Baby Monitor Security Camera

The performance of the baby monitor is reflected by its built-in parameters and function combination. The following shows some properties that a high-quality and applicable baby monitor should have. The requirements for baby monitors in this part apply to all audio/video, digital/analog home baby monitors and wireless baby monitors, and are not changed due to the combination mode of the monitoring end and the control end.

The size shall be as small as possible: the small baby monitor (monitoring end and control end) is more convenient to install and carry in the family.
Low power display: the baby monitor, especially the monitoring terminal, must work continuously for a long time. Once the product is low in power, it cannot remind parents to charge it in time. When the power continues to be consumed until it is exhausted, the control terminal will be unable to continue to receive any signal.
Voice trigger prompt: Voice trigger means that once the monitoring terminal detects the noise caused by the abnormal behavior of infants or children, it will be displayed at the control terminal through the noise prompt lamp.
The transmission signal frequency can be adjusted: the monitoring end of the baby monitor provides audio and video digital signals to the control end by transmitting wireless signals. If the transmission frequency of the monitoring end is not selected properly, it will produce electromagnetic interference with other household appliances, digital equipment, etc., which will affect the normal use of the product. Therefore, it is necessary to select a baby monitor that allows users to adjust the frequency of the transmitted signal at the monitoring end.
Adjustable volume: a friendly baby monitor will provide a volume selection knob or button at the control end. When parents are in an environment with loud background sound, they can hear the activity sound of babies and children by turning up the volume; When it is late at night or in a quiet environment, the low volume will not affect the normal rest of the people around you when you are answering normally.
VOX function: VOX is the abbreviation of sound activation start. The monitor with VOX function is in standby mode under normal conditions, and the screen and horn stop working, thus reducing the energy consumption of the product; Once it is detected that the monitored object has an abnormal sound exceeding the set standard, it will immediately flash its alarm lamp at the control terminal or directly light up the screen, and simultaneously play the audio and video information sent by the monitoring terminal.
Digital signals and analog signals: baby monitors using digital signals, such as Baohushen baby monitors, will have better transmission efficiency and provide users with clearer sound and picture quality; Moreover, digital signals can be encrypted to prevent being intercepted and interpreted by other receivers, effectively protecting users' family privacy; The electromagnetic signal interference of digital signal will be lower than that of analog signal, so as not to affect the normal work of other household appliances and equipment.
Monitoring end extension: The baby monitor with a friendly user experience should allow users to use one control end to manage the activities of several monitoring ends at the same time, especially in some families with multiple children. This good scalability not only reduces the trouble of carrying multiple control ends at the same time, but also reduces the objective additional expenses for these families.
Temperature display: some products will have the function of realizing the current indoor temperature, and even can set a critical value. Once the room temperature exceeds or falls below the critical value, an alarm signal will be sent. This is a very considerate function for temperature sensitive newborn children or sick children.
Intercom function: The high-end baby monitor allows parents to have a direct conversation with the baby (child) at one end of the monitoring end through the control end, so that children who are alone can provide psychological comfort. If children have any temporary needs or words, they can be known without bothering the guardian to run to the child.
Signal range: theoretically, the signal sent by the monitoring terminal can be received by the remote control terminal, which is more convenient for users to use the baby monitor flexibly. Now more and more families live in large family rooms, even multi-storey villas, and the baby monitor with strong signal receiving ability provides these families with a more convenient way of use. Parents no longer need to set the room beside the children in order to see and hear their children's every move. They can even take the control terminal to go out for a short walk!
Power supply mode: The baby monitor with built-in battery can automatically switch to the battery power supply mode when the external AC power supply is suddenly stopped, so that the user will not be affected to continue to monitor the child in the power failure environment.

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