The ketoconazole raw material is a white-like crystalline powder; it is odorless and tasteless. This product is soluble in chlorine, dissolved in methanol, slightly soluble in ethanol, and almost insoluble in water. Melting point This product has a melting point of 146 ° C. The specific rotation is taken from the product, accurately weighed, and methanol is added to make a solution containing 40 mg per 1 ml, which is determined according to law. According to the dry product, the specific rotation should be -1° to +1°. This product is a pink suspension.
Ketoconazole is an imidazole antifungal agent, and its mechanism of action is to inhibit the biosynthesis of the fungal cell membrane ergosterol, affecting the permeability of the cell membrane and inhibiting its growth. Ketoconazole can be used to treat superficial and deep mycosis, such as skin and nail files, white candidiasis, gastrointestinal fungal infections, etc., as well as caused by Candida albicans, coccidioides, histoplasmosis, etc. Systemic infection.
Its pharmacological effects:
1. Pharmacological ketoconazole is a pyrrole antifungal agent, which has antibacterial effect on deep-infected fungi such as Candida, Saccharomyces, Coccidioides, Basidaceae, Sporotrichum, etc. Fusarium and the like also have antibacterial activity. This product has weak effects on Aspergillus, S. skrjab, some dark spores, and mucor. By interfering with the activity of cytochrome P-450, this product inhibits the biosynthesis of the main sterol-ergosterol of the fungal cell membrane, damages the fungal cell membrane and changes its permeability, so that important intracellular substances leak. Ketoconazole inhibits the biosynthesis of fungal triacylglycerols and phospholipids, inhibits the activities of oxidases and peroxidases, and causes the accumulation of hydrogen peroxide in cells to cause submicrostructural degeneration and cell necrosis. Candida albicans inhibits the process of transforming from spores to invasive hyphae. Its pharmacological effects:
2. Long-term toxicity experiments of toxicological animals showed that ketoconazole can significantly increase alkaline phosphatase and degeneration of liver cells.
So go and identify?
Take about 10mg of this product, add 5ml of 0.1mol/L hydrochloric acid solution to dissolve, add a few drops of cesium iodide test solution, which will produce orange-red precipitate.
Take about 60mg of this product, put it in a 100ml volumetric flask, add 10ml of 0.1mol/L hydrochloric acid solution, dilute with water to the mark, shake well, take appropriate amount, and dilute with 0.01mol/L hydrochloric acid solution to make 15μg solution per 1ml. According to the ultraviolet-visible spectrophotometry (Appendix IVA of the Pharmacopoeia, 2010), it has the maximum absorption at the wavelengths of 221 nm and 269 nm, and a shoulder at the wavelength of 276 nm.
Warning: The State Food and Drug Administration issued a notice on June 25, 2015, saying that ketoconazole oral preparations have been discontinued in production and sales due to serious adverse effects of liver toxicity, and the drug approval number has been revoked; ketoconazole has been orally marketed. The preparation was recalled by the manufacturer before July 30th. The oral preparation of ketoconazole is an imidazole antifungal drug, and tablets and capsules are marketed in China.
Through the above introduction, what is the pharmacological effect of how to identify ketoconazole raw materials ? Have a certain understanding. I hope to help everyone.
Through the above introduction, what is the pharmacological effect of how to identify ketoconazole raw materials ? Have a certain understanding. I hope to help everyone.
medical Angio Closure Pad,angio syringe,Angio Closure Pad
Anesthesia Medical Co., Ltd. , https://www.jssinoanesthesias.com