US researchers have recently discovered that a new gene therapy based on the transformation of autologous hematopoietic stem cells may provide long-term immunity against HIV. In the new issue of the journal Science Public Library and Pathogens, the University of California, Los Angeles, Scott Kechin Laboratory and others reported that animal experiments show that their chimeric antigen receptor T cells (CAR-T) Therapy not only effectively identifies and eliminates HIV, but it can persist in the body for more than two years.
Zhai Anjie, co-first author of the paper and assistant researcher at the University of California, Los Angeles, told Xinhua News Agency that although "cocktail therapy" can minimize HIV replication and delay the disease process, it can not completely eliminate the virus, and the infected person needs to take the drug for life. Their idea is to improve the patient's own immunity through gene therapy, so that CAR-T cells can be "patrolled" in the body for a long time. Once the latent virus appears, it will be cleaned up in time to treat AIDS.
The specific approach is to use CAR-T therapy to improve the patient's own immune function, so that its T lymphocyte recognition and elimination of HIV is more powerful. Because HIV-infected cells need to bind to CD4 molecules, the researchers genetically engineered autologous hematopoietic stem cells to allow differentiated CAR-T cells to express fusion proteins containing CD4 molecules. When this fusion protein binds to HIV, CAR-T The cells are activated to remove the virus and infected cells.
"In the porpoise monkey experiment, we found that genetically engineered autologous stem cells can survive in the bone marrow for a long time without rejection and differentiate into CAR-T cells with anti-Ai function. In more than two years of the experimental cycle, we CAR-T cells can always be detected. Especially after the interruption of 'cocktail therapy', these CAR-T cells can significantly inhibit the virus," said An Jie.
She said that this study demonstrates for the first time in primates that genetically modified stem cells can improve anti-AIDS immunity for a long time, which has played a guiding role in HIV treatment and CAR-T immunotherapy against cancer. "Using stem cells to transform immunity Research is still in its infancy, and our research will lay the groundwork for other stem cell immune research (such as cancer) in the future.
CAR-T is an emerging therapy that has developed rapidly in recent years. This year, US regulators have approved two such therapies for cancer treatment, which is thought to open a new chapter in cancer treatment. (Xinhua)
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