Respiratory dysfunction is the leading cause of death and disability after spinal cord injury. According to a recent paper published by the British journal Nature Communications, US scientists report that the latest experiment has a long-term (up to one and a half years) spinal cord. Injured rats resumed respiratory control after receiving treatment with an enzyme injection.

Worldwide, the incidence of spinal cord injury is increasing year by year. Spinal cord injury is the compression or rupture of the spinal cord caused by various external forces acting on the spine. Its treatment and rehabilitation has become a major topic in the medical field today - and respiratory complications are the main causes of death in patients with high spinal cord injury. - The higher the injury site, the greater the effect on respiratory function.

The reason for this is that the nerve fibers that control the respiratory muscles often break after the spinal cord injury occurs, and scar tissue is gradually formed around these interrupted nerve fibers, thereby blocking the reconnection attempt. It has long been believed that these fibers die quickly if they are not reconnected quickly after injury.

This time, the latest experiments by Philip Warren, a researcher at Case Western Reserve University, USA, and colleagues show that after the chondroitin sulfate lyase ABC is injected into a region of the rat's spine, the neurons involved in the respiration are effectively decomposed. Scar tissue formed after spinal cord injury occurs.

The researchers found that after the scar tissue was removed, the nerve sprouted significantly, and rats with near-lifetime (up to a year and a half) respiratory paralysis eventually regained almost complete respiratory control. In addition, the team also found that combined with intermittent hypoxic conditions can enhance recovery and can be maintained for up to 6 months after treatment.

The researchers pointed out that further research is currently being carried out to determine the exact recovery mechanism for this finding.

Millions of people worldwide suffer from chronic spinal cord injury, and damage to different spinal segments will result in varying degrees of respiratory muscle dysfunction. It is generally believed that the long-term destructiveness of spinal cord injury to respiratory function is irreversible. But the researchers seem to have discovered the possibility of change, at least they found a solution in the rat. Injection of a special enzyme can help awaken certain types of nerve cells. Helping rats to restore their breathing control is only the first step. If this program continues to advance, it can help restore some of the motor function of rats, and even eventually it can be used in humans. That is the light that life science brings to the gray life of patients.

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