Wearable devices based on the principle of electrical stimulation help diabetic patients effectively control blood sugar

November 21, 2016 Source: Noble

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Although it can effectively treat diabetes, exercise is still difficult for overweight or the elderly. A new wearable medical device developed by Kumamoto University was found to affect visceral fat loss and improve blood sugar (sugar). The current study reports clinical trial results for optimal frequency of use.
Type 2 diabetes is a systemic organ failure disease that is mainly caused by chronic hyperglycemia and inflammation from accumulation of excess visceral fat. Metabolic disorders such as hyperglycemia weaken body pressure resistance and exacerbate insulin resistance. The ability of insulin to lower blood glucose levels is reduced and insulin secretion is reduced.
The heat shock response (HSR) is activated to respond to stress in the human body, but its function is reduced in patients with type 2 diabetes. A research team at Kumamoto University in Japan found that glucose-related abnormalities were improved by restoring HSP72 function (the main protein of HSR). The team found that mild appropriate electrical stimulation (MES) combined with thermal stimulation (HS) can activate HSP72 more effectively.
Researchers have developed a belt-type medical device that uses a special type of rubber to deliver MES and HS at the same time. The MES + HS clinical trial was then performed on obese men over 40 years of age with type 2 diabetes. The results showed fasting blood glucose levels, decreased visceral fat, improved insulin resistance, and significantly improved (-0.43%) glycated hemoglobin (HbA1c) values. About half of the subjects (52.5%) had less than 7.0% glycated hemoglobin, an indicator of diabetes. The first trial showed that activation of HSR produced better therapeutic results.
In the investigator's next clinical trial, 60 patients with amphoteric type 2 diabetes were treated with a 12-week banded MES + HS medical device. Subjects received 60 minutes of treatment each time and were divided into three groups of treatments twice, four times and seven times a week. This determines the most effective treatment frequency.
The visceral fat area was reduced by 5.37 square centimeters in the treatment group twice a week, 14.24 square centimeters in the treatment group 4 times per week, and 16.45 square centimeters in the 7 treatment sessions per week. Glycated hemoglobin decreased by 0.10%, 0.10%, and 0.65% in the treatment groups 2, 4, and 7 times per week, respectively. It also shows chronic inflammation, fatty liver markers, renal function and blood lipids. In addition, the addition of MES + HS in the treatment of DPP-4 inhibitors, which are the most commonly used treatments for diabetes in Japan, showed a stronger improvement in blood glucose.
“This device is very easy to use because it is simply connected to the abdomen and it has little effect on the patient. It can be expected to have an effect similar to exercise therapy,” said Dr. Tatsuya Kondo, who led the study. “Even in patients who have difficulty exercising, such as those who are overweight, elderly or have some form of disability, this device can provide acceptable treatment in addition to traditional diabetes treatment.”

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