Breakthrough in the study of degenerative changes in bone and joint

Breakthrough in the study of degenerative changes in bone and joint

January 10, 2019 Source: Health News

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Reporter Cheng Shouqin was informed by the Zhongda Hospital affiliated to Southeast University that the team of associate professors of the Department of Orthopaedic Surgery has made significant progress in the study of pathogenesis of degenerative changes in bone joints for more than five years. The first demonstration of miR-141/SIRT1/NF-κB The role of the signal-regulating axis in the degeneration of the intervertebral disc provides a new idea for the prevention and treatment of disc degeneration. The research paper was recently published in Nature Communication.

According to reports, intervertebral disc degeneration refers to the aging and degeneration of various tissues of the intervertebral disc such as nucleus pulposus, annulus fibrosus and cartilage endplate, and is the pathological basis of a series of degenerative diseases of the spine. Intervertebral disc degeneration-related diseases are the most common cause of loss of human labor capacity and quality of life, and bring a heavy economic burden to families and society. In order to reveal the specific pathogenesis of intervertebral disc degeneration, the Army research team used microRNA chip technology and quantitative PCR technology to determine the pathogenic factor, miR-141. Observing the natural history of intervertebral disc degeneration in miR-141 KO mice, silencing miR-141 can prevent degeneration of the intervertebral disc. Further in vitro studies have found that miR-141 can significantly affect the phenotype of nucleus pulposus cells. Gene expression profiling chips and bioinformatics studies have found that miR-141 targets and regulates SIRT1/NF-κB signaling pathways, thereby inhibiting degeneration of intervertebral discs. Injecting nanoparticle-encapsulated miR-141 into the mouse intervertebral disc significantly inhibited disc degeneration.

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