The Ontario Brain Research Institute (OBI) released a message that the Brain-CODE neuroinformatics platform, the first open access to high-resolution magnetic resonance (MR) imaging mouse models for the first time, will help research People explore how autism affects the brain, speeding up the process of finding better treatments and improving human health.
The open data includes 31 mouse models representing 23 genotypes from OBI's ongoing Neurodevelopmental Disabilities Research Project (POND) for more than 90 mouse models. The project was funded by the Ontario Brain Institute and supported by the Canadian Brain Program and the Canadian Institutes of Health, and was researched by the Sick Children's Hospital research team.
The research team collaborated with several international research groups to collect MR images of known genetic mutations associated with autism. These images identify key brain regions that affect autism, capture complex changes in brain structure throughout the mouse model, and provide critical insights into differences in autistic patients. The disclosure of this data set will attract researchers around the world to come up with questions about how the genetic basis of autism leads to changes in the brain network, and ask questions and answers.
Brain-CODE is a large-scale centralized informatics platform developed and maintained by the Ontario Brain Institute to collect, store, share and analyze data from the research project. Brain-CODE has so far accumulated 16,140 records, including 14,610 human records and 1,530 animal records involving cerebral palsy, depression, epilepsy, neurodegenerative diseases (such as Alzheimer's) and neurodevelopmental disorders (such as Five major research areas, such as autism, also store data sets from other studies.
The data in Brain-CODE is standardized and can be used to compare data sets for various brain disorders. This will allow researchers to explore issues that were previously impossible to reach, such as whether the depression experienced by people with epilepsy and dementia is different. (Technology Department)
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