Release date: 2018-04-23
A medical research paper published online by the British journal Nature recently said that a method of preserving liver for body temperature called "life support system" may help improve the transplant effect and increase the number of available donor livers, thereby reducing waiting for liver transplantation. Mortality rate.
Liver transplantation is a surgical treatment for the liver function of patients with end-stage liver disease. However, as the incidence of liver disease increases, the supply of liver for transplantation is in short supply. Many potential donor livers are considered too risky because they are very vulnerable to cryopreservation. Liver viability was not measured during cryopreservation because normal cellular activity was inhibited during this period.
The medical community believes that a potential solution is to maintain the donor liver at body temperature, that is, to provide oxygenated blood, drugs and nutrients to the donor liver through normal temperature mechanical perfusion (NMP), just like providing a life support system for patients. The liver can be preserved for 24 hours in this way, and in the future this method will also support monitoring of liver viability during treatment and repair as necessary.
This time, University of Oxford scientist David Nasrall and his colleagues conducted the first randomized trial of 220 liver transplant patients, comparing traditional frozen storage methods and room temperature mechanical perfusion methods. Based on the measurement of liver damage biomarkers, the team found that the normal temperature mechanical perfusion method had 50% less damage to the donor liver than the frozen storage method, an average liver preservation period of 54%, and an organ rejection rate of 50%. In addition, the researchers found that after one year of transplantation, the two methods did not differ significantly in the incidence of biliary complications and graft survival and patient survival.
Scientists at the University of Medicine in Innsbruck, Austria, wrote in an accompanying news and opinion article that this method of preserving organs in near-normal conditions not only helps to enhance liver transplantation, but also helps improve liver surgery and organs. Care.
Source: Technology Daily
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