Release date: 2016-09-27
Recently, researchers from the Karolinska Institute in Sweden reported that endurance training can alter the activity of many genes. The relevant research results were published in the international academic journal PLOS Genetics.
Routine endurance training is good for your health and can prevent cardiovascular disease, diabetes, obesity and other health problems. But scientists are not particularly clear about what kind of changes have taken place at the molecular level.
Researchers at the Karolinska Institute analyzed changes in RNA in muscle tissue before and after endurance training. They found that approximately 3,400 RNA transcripts associated with 2,600 genes have changed in response to endurance training. An important hint from this study is that training can induce the same gene to increase the synthesis of one RNA transcript and reduce the synthesis of another transcript. According to the researchers, this means that exercise can lead to functional changes in genes, such as the synthesis of specific protein variants over other variants.
The study included a total of 23 participants who developed a special exercise program to ensure that one participant's leg was active, the other leg was still, and muscle samples were taken before and after training. After 9 months of rest, they exercised two legs at the same time in the same way, collecting muscle samples from both legs.
The researchers said: "We hope to find any effects left by the previous training, that is, a muscle memory, to see if this muscle memory will affect the response to repeated training."
They found that changes in gene activity that occurred on previously trained legs no longer existed after the workout continued. However, the response of the trained and untrained legs to the repetitive training before the start of the second training phase is somewhat different, indicating that the exercise leaves other continuing effects.
This study is important for understanding how muscles work and how to adapt to endurance training. In the long run, it is possible to develop new and more precise drugs for those who are unable to exercise in order to prevent cardiovascular disease.
Source: Bio Valley
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