2016 accurate medical condition

2016 accurate medical condition

November 25, 2016 Source: Bio 360

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Accurate medical treatment, also known as personalized medicine, refers to the combination of proteome, metabolome and other relevant internal environmental information based on personal genomic information, to design the best treatment plan for patients, in order to maximize the treatment effect and minimize side effects. A customized medical model. In recent years, "precise medical care" has become a hot spot in the medical industry at home and abroad.

In February 2016, researchers at the University of Iowa in the United States applied individualized proteomics to develop a precise treatment strategy for a patient with an eye disease, and published the results in the international academic journal JAMAOphthalmology. An important step in the accurate diagnosis and treatment of diseases.

On March 5th, precision medicine (genomics) was selected into 100 major projects in the "13th Five-Year Plan". On March 8th, the “Notice of the Ministry of Science and Technology on the publication of the 2016 National Key Project Application Guidelines for the Accurate Medical Research of the National Key R&D Programs” (referred to as the “National Guide”) was announced on March 8th, and the major scientific research activities for precision medical treatment were opened. The prelude. The national guidelines are clear, and precision medicine will be one of the key priorities for this year's priority, and will officially enter the implementation phase.

On April 15, the National Health and Family Planning Commission and the Ministry of Science and Technology organized more than 30 experts in the fields of biomedicine, bioinformatics big data and clinical medicine, as well as the Chinese Academy of Sciences, the Ministry of Health and the National Natural Science Foundation. Leaders will jointly discuss the implementation principles, objectives and key contents of the precision medical research plan, and plan our medical development strategy.

In May, Australian Prime Minister Malcolm Turnbull announced the Zero Childhood Cancer Program. The program aims to use genomic technology to provide individualized treatment strategies for childhood cancers that are currently incurable.

In June, the White House issued a draft data security framework related to precision medical plans. The draft recommended that participants in precision medicine should establish a safety plan based on overall risk and establish a corresponding management system to ensure data security. At the same time, the White House also requires participating institutions to find third-party agencies to help them test and confirm the security of existing data.

On June 25th, the National Science and Technology Management Information System Public Service Platform issued the “Notice on Publicizing the 2016 Annual Project Arrangement of the National Key R&D Program “Precision Medical Research”, and the “Special Precision Medical Research” key special project is expected to enter the review session 2016. The annual project information is publicized. 61 projects entered the publicity list, and the central government's financial support totaled 640 million yuan.

At the end of June, the French government announced an investment of 670 million euros to start the genomic and individualized medical project, and named it: France Genomic Medicine 2025. The project aims to improve national medical diagnosis and disease prevention capabilities. It is expected to establish 12 gene sequencing platforms and 2 national data centers nationwide.

On July 7, the FDA issued two draft guidelines, “FDA-Based Oversight Standards for In Vitro Diagnosis of Genital Diseases Based on NGS Technology.” “Using the Public Human Genetic Difference Database to Support the Clinical Effectiveness of NGS-Based In Vitro Diagnostics ", aimed at further accelerating the promotion of precision medical plans.

In early July, Obama announced that he would invest $55 million in the fiscal year to build a precision medical public database that would cover the detailed health information of more than 1 million volunteers for disease research and the beginning of personalized medicines and therapies.

In July, led by the National Development and Reform Commission and the Zhejiang Provincial Development and Reform Commission issued the “Zhejiang Genetic Testing Technology Application and Demonstration Center Construction Plan” (Zhefa Development High Technology [2016] No. 65, hereinafter referred to as “Demonstration Center Construction Plan”), officially approved The construction of a demonstration center such as the "Application of the Technology for the Detection of Polygenic Genes" is planned to be completed in 2017.

On July 8th, the review of NatureReviewsCancer revealed the development status of biomarkers in the field of precision medicine. The lung cancer was used as an example to outline four promising biomarkers, and the challenges faced by national precision medical research were also carried out. Analysis. The four biomarkers are: tumor immune and microenvironment biomarkers, genetic variation biomarkers, epithelial-mesenchymal transition-related biomarkers, therapeutic resistance and susceptibility biomarkers.

In September, two articles that pushed "precise medical care" onto the trial table attracted widespread attention. One was published in the journal Nature and the other in the New England Journal of Medicine. Two articles summarize the clinical results of some of the recently published individualized treatments for cancer, but all give very pessimistic comments.

On October 21st, the China-US Inspection Masters Forum was held in Shanghai. The forum invited experts from the Chinese and American inspection fields to talk about “exact inspection and precision medicine”. At the meeting, a number of experts based on individualized diagnosis and treatment, through the introduction of advanced detection technology, emphasized the importance of precision medicine.

I have to admit that there is a bubble in precision medicine, but Xiao Bian believes that there is always a day when the bubble is squeezed out. Precision medicine is achievable and not too far away.

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