Three domestic "Molecular Cell" published simultaneously online

September 26, 2016 Source: BioArt

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On the evening of September 22, Molecular Cell published three important results from domestic research institutes online. Coincidentally, ten days ago, "Cancer Cell" also published three results from domestic researchers in the same issue. In addition, a week ago, "Nature" also published two important papers from Tsinghua University and Tongji University at the same time. In addition, on August 21st, Yang Maojun's research group at the Center for Structural Biology of Tsinghua University published a large article entitled "Mammalian Respiratory Structure" in "Nature", which is the highest resolution so far. The mitochondrial respiratory chain supercomplex—the three-dimensional structure of the cryo-electroscope of the respiratory body. The fun is that Teacher Yang’s national “Jie Qing” is still in the publicity period, and this “Nature” long article is strong.
 
September is the first month of the new school year. It is really gratifying to have so many research groups in China to send out "great gifts" at the beginning of the new school year. This fully demonstrates the development momentum of the domestic life sciences. The above three "Molecular Cell" articles are mainly from:
 
Li Guohong, Research Group of the Institute of Biophysics, Chinese Academy of Sciences, and Li Ming, the Institute of Physics;
 
Cui Wei and Huang Jun of Sun Yat-Sen University and the research group and Rong-Fu Wang of Cornell University;
 
Chen Yuhang Research Group of the Institute of Genetic Development, Chinese Academy of Sciences and Fei Li Group of New York University
 
Li Guohong's research group titled "FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription" is based on a further study of the "30nm Chromatin Fiber Advanced Structure" reported in the 2014 Science. The 30nm chromatin is formed by the distortion of four nucleosomes. The new study uses single-molecule force spectroscopy. The results show that the structural units of the four nucleosomes are stained. The assembly of the fiber appears to be a stable secondary structure, and this stability is related to the histone chaperone FACT. Experiments in yeast further revealed that transcription of the FACT coordinating gene was triggered by instability of the four nucleosome basic structural units on 30 nm chromatin from the genome-wide level. The experimental results also found that the linker histone H1 page is involved in the stabilization and folding of this nucleosome. The results of this study indicate that the four nucleosome basic structural units are the regulatory structural units of chromatin fibers, which has a deeper significance for further understanding of the transcriptional regulation of 30nm chromatin.
 
Li Guohong, Ph.D. Supervisor, National Jieqing, winner of the “Hundred Talents Program” of the Chinese Academy of Sciences, Institute of Biophysics, Chinese Academy of Sciences, State Key Laboratory of Biomacromolecules, and leader of the Innovation Project Team. 1991-1995, Bachelor of Science, Department of Virology, Wuhan University; 1995-1998, Master of Science, Department of Biophysics, Beijing Medical University; 1998-2003, Institute of Cellular Biology, Germany, Department of Biology, University of Heidelberg, Ph.D. Degree; 2003-2009, Howard Hughes Medical Research Institute (HHMI), postdoctoral. 2009- Present Institute of Biophysics, Chinese Academy of Sciences, Research Fellow of the "Hundred Talents Program" of the Chinese Academy of Sciences, doctoral tutor. In recent years, his research results have been published in internationally renowned journals such as Science, Cell, Molecular Cell, Genes & Development and Developmental Cell, and have received great attention in the field.
 
The article entitled "TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses" from Sun Yat-Sen University's research group focuses on the regulation mechanism of natural immunity. Cyclo-GMP-AMP synthetase (abbreviated as cGAS) is an important DNA viral receptor that initiates an antiviral immune response by stimulating type I interferon signaling to produce cGAMP. The results of this study showed that type I interferon can induce the production of TRIM14, thereby increasing the stability of cGAS by recruiting the ubiquitinase USP14. The TRIM14 mouse knockout model showed that the ability of Trim14-/- mice to produce type I interferon was greatly reduced, making them more susceptible to death in the process of infection with HSV-1 virus.
Cui Wei, born in 1982. Professor and doctoral tutor at the School of Life Sciences, Sun Yat-Sen University. The National Youth Thousand Talents Program is selected. In 2012, he was selected into the “Hundred Talents Program” of Shan University. Professor Cui Wei has long been engaged in the research of innate immune system identification and regulation, signal transduction mechanism and disease correlation, and has done research in the fields of experimental biology (especially molecular immunology) and computational biology (the establishment of mathematical models of biological signaling networks). He has published many outstanding works and has published more than 20 academic papers, including 13 articles by the first author and correspondent authors, including top journals such as Cell, Immunity, Nature Immunology, Cell research, and Biophysical Journal.
 
The third research paper entitled "Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading" is the first unit of the University of New York. The researcher of the Institute of Genetics of the Chinese Academy of Sciences is a co-author. CENP-A is a variant of histone H3 in the centromere region and is a key epigenetic factor for the establishment and function of the centromeric region. This work identified an unknown NAP family protein, Ccp1, in fission yeast that antagonizes the loading of CENP-A in the centromeric and non-centromeric regions. Further findings indicate that Ccp1 is able to cooperate with H2A.Z to block the assembly of CENP-A on euchromatin. From the results of this paper, Chen Yuhang Research Institute is mainly involved in the structural analysis part, and the theme of the thesis is completed by the New York University Fei Li group.
 
Dr. Chen Yuhang, researcher, doctoral tutor. In 1998, he obtained a Bachelor of Science in Pharmacy from Beijing Medical University (now Peking University School of Medicine); in 2002, he received a Ph.D. in Biophysics from Tsinghua University; from 2002 to 2012, he was a postdoctoral researcher at Columbia University; in November 2012, he was inherited. Investigator with the Institute of Developmental Biology; In 2012, he was selected into the “Youth Thousand Talents Program”. Chen Yuhang's research group is mainly engaged in the field of structural biology, using a combination of protein crystallography, single-particle cryo-electron microscopy and electrophysiology to study the molecular mechanism of ion channel protein structure and function regulation.

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