Release date: 2016-05-30

Academician Ge Junbo took the lead in successfully completing the implantation of the first fully degradable polylactic acid stent developed by the Chinese people. This makes the coronary stent not to be in the body for a lifetime, so that the degradable stent is beneficial to patients with coronary heart disease.

Traditional bracket

Stent implantation is a common clinical treatment for coronary heart disease, but the third-generation metal drug-eluting stent (the stent is soaked with drugs) is still commonly used in China. This stent has many side effects. Once implanted, the metal stent is accompanied by the patient's body for life. In addition, due to the rejection of the body's foreign metals, it is easy to cause blood clots and endanger the lives of patients, so it is also called "untimed bombs."

Degradable stent

Scientific research has found that coronary stents do not need to be in the body for a lifetime, but have a "service" cycle. After 6 months of interventional coronary artery, the stent has completed its mission and can “return” to restore the blood vessel to its original appearance.

Recently, Academician Ge Junbo took the lead in successfully completing the implantation of the first fully degradable polylactic acid stent (XinsorbTM) independently developed by the Chinese. The stent was constructed from a polymer polylactic acid material to construct a rapamycin drug release platform and implanted into the body. It is completely degraded and absorbed within 2-3 years, which is different from traditional metal drug stents.

This indicates that China's stent research and development level has stood at the forefront of the international, and also represents the "fourth revolution" of cardiovascular intervention in the treatment of coronary heart disease in China. A new generation of fully degradable stents will enter the clinic and will benefit more patients with coronary heart disease.

The new fourth-generation degradable stent has degradable properties. It takes a short time after implantation and does not affect the function of the blood vessels. The incidence of thrombosis in the stent is extremely low. The probability of restenosis is extremely low, and it does not affect the coronary artery in the later stage. Bypass surgery.

Principle of biodegradable stent


The fourth-generation stent design concept is: for a period of time after stent implantation, it will mechanically support the narrow coronary vessels, and release drugs to prevent restenosis, after which the stent is slowly degraded and completely absorbed by the tissue. The vascular structure and the systolic function completely return to the natural state.

Four generation bracket large PK

Degradable stents can be used to open blocked blood vessels and restore blood flow to the heart, just like traditional metal drug-eluting stents. However, unlike metal stents, fully biodegradable stents are made of a special material that dissolves over time after opening a blocked vessel, leaving no metal stents in the patient's blood vessels. The blood vessels restore more self-function and exercise capacity.

It is important that the stent is autolyzed and the long-term benefits of returning the blood vessel to a more natural state. Professor Ge Lei from Zhongshan Hospital affiliated to Fudan University introduced that biodegradable stent technology can restore the integrity and function of blood vessels to a natural state, which will provide patients with unique physiological benefits. And reduce the incidence of thrombosis, and does not affect the progress of coronary artery bypass grafting.

China's self-developed fully degradable stents have a great benefit for patients, which is more cost-effective.

Source: MacKota Medical Finishing

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