[ China Pharmaceutical Network Health Health ] The kidney plays a vital role in the human body. In life, some drugs we sometimes eat have certain damage to the kidneys. Adverse reactions of the kidney to therapeutic doses and toxic reactions due to excessive drug use or irrational application may result in drug-induced renal damage. Let me introduce you about the drugs.
Which kinds of drugs are easy to damage the kidneys
The kidney is the main organ of drugs, poisons and excretion in the human body. Some substances can cause damage to the kidney in many ways. With the increase of age, the metabolism and detoxification function of the kidneys of the elderly are significantly reduced, and renal failure is easily affected by various factors. Many drugs are widely used in the elderly, which increases the incidence of kidney damage in the elderly.
Various antibiotics
Aminoglycosides such as neomycin and gentamicin are the most antibiotics with nephrotoxicity, and their toxicity is related to the time and dose of administration. Penicillin and cephalosporin itself have no obvious nephrotoxicity, mainly causing allergic renal interstitial damage, regardless of drug dose. In addition, elderly patients taking sulfa drugs may also have acute renal failure.
Anti-inflammatory analgesics
Indomethacin, sulindac, ibuprofen, naproxen, aminopyrine, phenacetin, phenylbutazone, aspirin, analgin and other anti-inflammatory analgesics, easily cause kidney damage in the elderly, especially The original liver and kidney disease, or diarrhea, dehydration, resulting in insufficient blood volume is particularly likely to occur.
Antihypertensive drugs
Special attention should be paid to the renal damage caused by angiotensin-converting enzyme inhibitors (such as captopril and enalapril) in antihypertensive drugs, which often occur with clinicians failing to strictly control the indications of drugs and not discovering potential in time. Risk of kidney failure, these potential risks include renal artery stenosis, polycystic kidney disease, heart failure, combined with diuretics.
Contrast agent
Older people use contrast agents to cause a higher incidence of kidney disease. The original kidney disease, dehydration, and a large number of patients who injected contrast agents in a short period of time have a higher incidence of renal damage.
Antineoplastic agents
Kidney damage caused by antineoplastic agents such as cisplatin and mitomycin is often associated with excessive doses.
Chinese herbal medicine
Reports of kidney damage caused by Chinese herbal medicine have been increasing in recent years. There are many kinds of traditional Chinese medicines with nephrotoxicity. The common ones are: Tripterygium wilfordii, Rhizoma sylvestris, Mutong, Masanguo, P. chinensis, Xanthium, Poppy, Tuwu, Tianma, Lameigen, Gentleman, Motherwort, Baihuadan And fat sea, etc., which caused the most damage to the kidney caused by Tripterygium wilfordii, followed by Mutong. Kidney damage caused by excessive use of the above-mentioned Chinese medicines accounts for a large proportion (90%), and it is believed that the use of prescriptions for medical treatment and non-medical use also account for a large proportion (33%).
The key to preventing drug-induced renal damage lies in popularizing common sense of medicine and monitoring the monitoring of adverse drug reactions. It should be profoundly recognized that good medicines also need to be used properly. Non-prescription drugs and Chinese herbal medicines are not completely harmless. Resolutely resist all kinds of fake and inferior drugs. Once the drug is suspected to cause kidney damage, suspicious drugs should be discontinued immediately, and dynamic observation, sometimes requiring dialysis treatment, can save lives.
In short, we must always pay attention to the health of the kidneys. When you use the medicine, you must carefully read the instructions of the medicine to see if the medicine will affect the health of the kidney. At the same time, you should use the medicine correctly under the guidance of a doctor.
(Cautious medication 6 major drugs are easy to damage the kidneys)
Which kinds of drugs are easy to damage the kidneys
The kidney is the main organ of drugs, poisons and excretion in the human body. Some substances can cause damage to the kidney in many ways. With the increase of age, the metabolism and detoxification function of the kidneys of the elderly are significantly reduced, and renal failure is easily affected by various factors. Many drugs are widely used in the elderly, which increases the incidence of kidney damage in the elderly.
Various antibiotics
Aminoglycosides such as neomycin and gentamicin are the most antibiotics with nephrotoxicity, and their toxicity is related to the time and dose of administration. Penicillin and cephalosporin itself have no obvious nephrotoxicity, mainly causing allergic renal interstitial damage, regardless of drug dose. In addition, elderly patients taking sulfa drugs may also have acute renal failure.
Anti-inflammatory analgesics
Indomethacin, sulindac, ibuprofen, naproxen, aminopyrine, phenacetin, phenylbutazone, aspirin, analgin and other anti-inflammatory analgesics, easily cause kidney damage in the elderly, especially The original liver and kidney disease, or diarrhea, dehydration, resulting in insufficient blood volume is particularly likely to occur.
Antihypertensive drugs
Special attention should be paid to the renal damage caused by angiotensin-converting enzyme inhibitors (such as captopril and enalapril) in antihypertensive drugs, which often occur with clinicians failing to strictly control the indications of drugs and not discovering potential in time. Risk of kidney failure, these potential risks include renal artery stenosis, polycystic kidney disease, heart failure, combined with diuretics.
Contrast agent
Older people use contrast agents to cause a higher incidence of kidney disease. The original kidney disease, dehydration, and a large number of patients who injected contrast agents in a short period of time have a higher incidence of renal damage.
Antineoplastic agents
Kidney damage caused by antineoplastic agents such as cisplatin and mitomycin is often associated with excessive doses.
Chinese herbal medicine
Reports of kidney damage caused by Chinese herbal medicine have been increasing in recent years. There are many kinds of traditional Chinese medicines with nephrotoxicity. The common ones are: Tripterygium wilfordii, Rhizoma sylvestris, Mutong, Masanguo, P. chinensis, Xanthium, Poppy, Tuwu, Tianma, Lameigen, Gentleman, Motherwort, Baihuadan And fat sea, etc., which caused the most damage to the kidney caused by Tripterygium wilfordii, followed by Mutong. Kidney damage caused by excessive use of the above-mentioned Chinese medicines accounts for a large proportion (90%), and it is believed that the use of prescriptions for medical treatment and non-medical use also account for a large proportion (33%).
The key to preventing drug-induced renal damage lies in popularizing common sense of medicine and monitoring the monitoring of adverse drug reactions. It should be profoundly recognized that good medicines also need to be used properly. Non-prescription drugs and Chinese herbal medicines are not completely harmless. Resolutely resist all kinds of fake and inferior drugs. Once the drug is suspected to cause kidney damage, suspicious drugs should be discontinued immediately, and dynamic observation, sometimes requiring dialysis treatment, can save lives.
In short, we must always pay attention to the health of the kidneys. When you use the medicine, you must carefully read the instructions of the medicine to see if the medicine will affect the health of the kidney. At the same time, you should use the medicine correctly under the guidance of a doctor.
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