Release date: 2018-02-07
It is reported that drug addiction is a serious social problem. Although there are many ways to effectively detoxify addicts and relieve addiction symptoms, even if the detoxification is long-term, when the detoxification encounters environmental factors, it is still easy to activate the addiction that has been "deep buried". Memory leads to drug relapse. How does environmental factor reactivate addictive memory? This has always been an important issue for global brain science researchers.
The Zheng Ping team's research shows that environmental factors "double activation" in the brain's prefrontal cortex to the amygdala nerve circuit, or environmental factors to reactivate the drug's important neural mechanism of withdrawal memory. This means, in the future, by intervening in this process or as a new strategy for reducing drug exposure leading to drug relapse.
According to reports, in order to solve the mystery of addictive memory, five years ago, Zheng Ping team began scientific research. The researchers placed morphine-addicted mice in two boxes with different environments: boxes with an "addiction" environment were black, and boxes without an "addiction" environment were white. In the black (environment) box, the research team suddenly “quits†morphine after injecting an addictive needle into the addicted mouse. At this point, the addicted rat produces a painful "withdrawal" symptom that forms a "stop" memory and associates the memory with the black environment in which it is located.
The researchers found that environmental factors could activate the associated neural circuits in the "cell body" and "nerve endings" of the addicted mice. Further studies have shown that up-regulation of the "molecular" of gene expression regulation in the neural circuit can significantly inhibit the reactivation of addictive memory by environmental factors. According to reports, relevant research results have been published in the latest issue of the international authoritative journal "BMC Biology" ("BMC Biology").
Source: Zhongxin Net
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