Pharmacological effects
1. Aphrodisiac effect: Experiments show that: Cuscuta has the effect of improving the vitality of Drosophila, making its mating rate significantly increased, and its strength is positively related to the concentration of drug administration. For the "Yang-Deficiency" model of mice caused by hydrocortisone, using Cuscuta seedlings could restore the symptoms of Yang deficiency, but failed to restore the animals to normal control levels. Experiments show that: Dodder decoction to gavage Yang deficient mice, can make their body weight, kidney weight, thymus weight, white blood cell count, red blood cell count, hemoglobin and superoxide dismutase activity increased significantly; to male mice Gavage can significantly prolong the swimming time of mice and the survival time under hypoxic conditions, and also enhance the non-specific resistance of mice.
2. Effects on Endocrine: It has been reported that the water extract of Cuscuta chinensis can increase the weight of the anterior pituitary, ovary and uterus of female rats, but has no effect on the level of luteinizing hormone (LH) in plasma; The number of HCG/LH receptors in the ovaries of rats increased, but the Ka value decreased compared with the control group. The water extract of Cuscuta chinensis can administer gavage to ovariectomized rats, which can increase LH secretion after injection of luteinizing hormone-releasing hormone (LRH) in the pituitary of ovariectomized rats. The plasma LH level is highest at 90 minutes after injection and can be increased by 241.58. %. Therefore, the report believes that Cuscuta can increase hypothalamic-pituitary-ovarian luteal function, not because they directly stimulate the secretion of pituitary luteinizing hormone, but because of the increased pituitary response to LRH and ovarian response to LH. .
3. The effect on heart rate and blood pressure: Dodder of dodder seeds (made with dodder and bean cake), infusions, and tinctures can increase the contractile force of the isolated heart. The former can increase the heart rate, while the latter two reduce it. Anesthetized dogs are given intravenously to lower their blood pressure.
4. Delayed the formation of cataract: The study showed that the water extract of Cuscuta gavage rats, delayed the action of cataract caused by taking galactose, the percentage of transparent lens was 33.3%. Its mechanism of action is that Cuscuta can reduce the activity of aldose reductase in cataract rats induced by galactose, enhance the activity of polyol dehydrogenase, hexokinase and glucose-6-phosphate dehydrogenase, and inhibit and correct the cataract rat lens. Abnormal changes in enzymes.
5. Other effects: Cuscuta whole plant water extract 1g/kg gavage to mice, can significantly reduce the electrical stimulation of mice caused by excitability and claudication, can make phenobarbital anesthesia in hypoxic mice Increased effect and longer survival time. The extract can antagonize the amphetamine-induced stimulatory effects and show a clear analgesic activity.
The hot water extract of Cuscuta can significantly delay the growth of skin tumors and the spread of malignant tumors caused by 7,12-dimethylphenylpropanone (DMBA) in mice.
Studies have shown that: Cuscuta on mouse myocardial homogenate catalase activity, brain homogenate catalase activity, brain homogenate lactate dehydrogenase activity is not obvious, but the activity of lactate dehydrogenase in myocardial homogenate There is a clear enhancement.
Silkworm mulberry silkworm immersed in silkworm decoction (20%) has a prolonged effect on the larval stage and total survival time of silkworms.
The aqueous solution of Cuscuta alcohol can significantly inhibit the synthesis of DNA of Ehrlich ascites cancer cells with 3H-TdR incorporation, suggesting its anti-cancer effect.
In vitro experiments showed that 100% dodder seed decoction had inhibitory effects on Staphylococcus aureus, Shigella flexneri, and Salmonella typhi.
Cuscuta ethanol extract has the effect of promoting the growth of myeloid progenitor cells.
Dodder - Medication Contraindications
1. "Ben Cao Jing Shu": kidney family phase fire, strong Yang insult who are bogey, dry stool who are also bogey.
2. "combined with Materia Medica": pregnant women, blood clotting, Yang Qiang, will knot, kidney fire, yin fire, six disabled.
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