Release date: 2014-07-24
Pancreatic cancer is a particularly serious disease that was rated as one of the ten most deadly cancers in 2013, and at least 94% of those who suffer from this disease will die within five years. Researchers at the University of Washington have developed a low-cost device, like a credit card, that helps pathologists diagnose pancreatic cancer earlier and faster, allowing clinicians to organize tissue without the need for a needle. The prototype is entered into the prototype, which can rely on the properties of the microfluidics to perform the basic steps of processing the biopsy tissue. The research team presented this scientific achievement paper at the International Society for Optical Engineering (SPIE) this month and will soon apply for patents for related first-generation equipment and future technological advancements.
According to a recent report by the Physicist Network, Eric Sebel, professor of mechanical engineering at the university and director of the Human Photonics Laboratory, said: "This new device is expected to help pathologists make diagnoses more quickly and more accurately. To determine how the cancer that has been invaded has changed, thus improving accuracy.†The main author of the paper, Ronnie Das, a postdoctoral fellow in bioengineering at the university, said: “As long as you cut an organization, you will lose some of it. If you can maintain the original intact tissue biopsy, you can observe the connections, cell morphology and structure that appear to be in the body, and you can see the whole situation of abnormal cell growth."
Currently, pathologists biopsy tissue samples by sending them to the lab for dicing, staining, and placing slides, and then analyzing the abnormalities. The new instrument will basically automate and simplify the manual and time-consuming process of pathology laboratory diagnosis of cancer. The technology is capable of processing and analyzing whole tissue sections, providing a more complete three-dimensional picture of the tumor cells.
The research team will build a thin, flexible silicon device that allows a piece of tissue to pass through tiny channels and repeat a series of larger steps that occur in the pathology laboratory. The device utilizes the properties of microfluidics to allow tissue to move freely without the need to apply significant external forces, through small passages and stops.
The device is simple to manufacture and use. The researchers first created a mold using a petri dish and a Teflon tube, then poured it into a viscous silicon material into a mold to create a small, transparent, curved and straightened channel. instrument.
Following the same steps in the pathology laboratory, the researchers used this instrument to treat tissue biopsies in a solid manner. They want all the next steps to be combined into a more powerful device, including 3D imaging, which is then built and optimized in the lab.
The researchers said the technology could treat biopsy sections as an over-the-counter kit and then send this information from remote areas to pathologists looking for signs of cancer. In addition, it has the potential to reduce the time required to diagnose cancer, in just a few minutes.
Source: Technology Daily
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