[China Pharmaceutical Network Technology News] It is reported that Singapore scientists have recently made significant progress in brain science research and successfully created a mini human brain in the laboratory. The purpose of this study is to hope that these miniature versions of the human brain can be used for the research and treatment of Parkinson's disease.
It is understood that Parkinson's disease is a chronic central nervous system degenerative disease, which mainly affects the patient's exercise capacity. Currently there are more than 2 million patients in China.
The cause of Parkinson's disease is mainly due to the rapid degeneration of neurons in the midbrain of the human body that control the motor skills of various parts of the body. These neurons cannot produce enough neurotransmitter dopamine, resulting in the inability to transmit information effectively, thus causing various movements. obstacle. At the same time, in the midbrain of patients with Parkinson's disease, the neuroprotective neurotropin level is significantly decreased, which accelerates the degradation rate of dopaminergic neurons.
In a collaboration between the Institute of Genetics of the Singapore Institute of Science and Technology (A*STAR) and the National University of Singapore Medical School, scientists have successfully grown using stem cell proliferation and differentiation techniques and three-dimensional cell culture techniques. Midbrain tissue about 2-3 mm in size. These miniature versions of the midbrain tissue are characterized by the human midbrain, including functionally active dopaminergic neurons and the ability to secrete neuromelanin. This is also the first time that neuromedin secretion has been observed in neural tissue cultured in vitro. With these artificial midbrains, researchers can simulate lesions in Parkinson's patients to find drugs that can treat Parkinson's disease.
Professor NgHuck Hui, Executive Director of the Singapore Gene Research Institute, who participated in the study, said: "Considering that the biggest difficulty in Parkinson's disease research is that it is impossible to test directly in the human brain, our results have taken a big step. These artificial midbrains It will be able to replace the currently used animal models to help us better understand the pathology of the human brain in Parkinson's disease and other neurological diseases."
Another participant in the study, Professor TanEngKing of the National University of Singapore Medical School, stressed: "The brain is the most complex tissue in the human body. Chronic brain diseases are a huge challenge for doctors and patients. We have achieved this. Achievements will be milestones in the search for brain disease therapies."
Although scientists admit that there is still a long way to go to truly cure Parkinson's disease, we hope that this research will greatly accelerate our understanding of the disease and the process of drug screening.
It is understood that Parkinson's disease is a chronic central nervous system degenerative disease, which mainly affects the patient's exercise capacity. Currently there are more than 2 million patients in China.
The cause of Parkinson's disease is mainly due to the rapid degeneration of neurons in the midbrain of the human body that control the motor skills of various parts of the body. These neurons cannot produce enough neurotransmitter dopamine, resulting in the inability to transmit information effectively, thus causing various movements. obstacle. At the same time, in the midbrain of patients with Parkinson's disease, the neuroprotective neurotropin level is significantly decreased, which accelerates the degradation rate of dopaminergic neurons.
In a collaboration between the Institute of Genetics of the Singapore Institute of Science and Technology (A*STAR) and the National University of Singapore Medical School, scientists have successfully grown using stem cell proliferation and differentiation techniques and three-dimensional cell culture techniques. Midbrain tissue about 2-3 mm in size. These miniature versions of the midbrain tissue are characterized by the human midbrain, including functionally active dopaminergic neurons and the ability to secrete neuromelanin. This is also the first time that neuromedin secretion has been observed in neural tissue cultured in vitro. With these artificial midbrains, researchers can simulate lesions in Parkinson's patients to find drugs that can treat Parkinson's disease.
Professor NgHuck Hui, Executive Director of the Singapore Gene Research Institute, who participated in the study, said: "Considering that the biggest difficulty in Parkinson's disease research is that it is impossible to test directly in the human brain, our results have taken a big step. These artificial midbrains It will be able to replace the currently used animal models to help us better understand the pathology of the human brain in Parkinson's disease and other neurological diseases."
Another participant in the study, Professor TanEngKing of the National University of Singapore Medical School, stressed: "The brain is the most complex tissue in the human body. Chronic brain diseases are a huge challenge for doctors and patients. We have achieved this. Achievements will be milestones in the search for brain disease therapies."
Although scientists admit that there is still a long way to go to truly cure Parkinson's disease, we hope that this research will greatly accelerate our understanding of the disease and the process of drug screening.
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