The first case of mcr-1 polymyxin infection in the United States
May 30, 2016 Source: US and Chinese medicine source
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, a patient with urinary tract infection resistant to polymyxin was reported in the United States. This bacterial resistance is caused by the plastid being infected by a gene called mcr-1, which is easily spread in bacteria, so this case is worrying. This is said to be the first case of mcr-1 resistant bacteria in the United States. Polymyxin is called the last line of defense against antibiotics, especially against Gram-negative bacteria. Many cases have been reported in China last year, and other countries such as Thailand and Denmark also have such infections. But this person has not been to other countries recently, so experts suspect that there are also super-resistant bacteria in the United States.
Polymyxin is a very old antibiotic that is very effective against Gram-negative bacteria. However, due to the nephrotoxicity and structural complexity of these antibiotics, there have been very few studies on these years of derivatives. Bacteria that are resistant to polymyxin are not uncommon because of the serious abuse of such antibiotics in the livestock industry. It is said that China's annual consumption reaches 12,000 tons, so there are a large number of resistant bacteria in the soil.
Although polymyxin is called the last line of antibacterial, other antibiotics are called the last line of defense, such as vancomycin and carbapenem. So even though this case is worrying, we did not immediately return to the era of antibiotics. Many media reports are somewhat exaggerated. But a professor at Harvard University said that the best way to prevent this type of infection is to wash hands frequently, which is a bit chilling, suggesting that there may be limited treatment if it hits it.
In the era of physical labor and the need to compete for resources with other animals every day, infection is the greatest threat to human survival, so it is not surprising that anti-infective drugs are the origin of the pharmaceutical industry. As early as the 19th century, young Perkin tried to synthesize antimalarial quinine based on the extremely limited knowledge of organic chemistry at the time. The method he used was not possible to synthesize quinine, but he unexpectedly got indigo and opened up the printing and dyeing industry. A large amount of dye is synthesized at a time. When people began looking for antibacterials in the early 20th century, a dye called Bailang Dumb was the first antibacterial. Those who believe in scientific superstition may think that this is someone who is pointing at it.
Later, the emergence of antibiotics greatly controlled the threat of infection to human health, and it was controlled that almost no bacterial infection could not be cured. But the bacteria have lived on the earth for more than 30 billion years, and they have also struggled with antibiotics for 3 billion years (most of the antibiotics come from the fight between bacteria), so they will not disappear because humans find several antibiotics, and the resistant bacteria are destined to appear. . However, before the emergence of drug-resistant bacteria in large quantities, the pharmaceutical industry did not know which types of drug-resistant bacteria would appear. Second, even if they knew to find drugs, the market did not exist. While the patent life and development costs of antibiotics are no different from other drugs, this unprofitable field has little research and development activity in recent years.
However, the emergence of all antibiotic-resistant bacteria is only a matter of time. Various suggestions for encouraging the development of antibiotics are emerging one after another, but so far there is no more effective incentive than the market to regulate this invisible hand. Some people are destined to die of super-resistant bacteria, but super-resistant bacteria will certainly be conquered by the pharmaceutical industry. What happens in the middle of this is only God knows, all we can do is wash our hands.
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