Professor Zhang explained in detail the three liquid biopsy techniques that are currently used in the field of gynecological oncology. Later, the reporter interviewed Professor Zhang on the progress and future of liquid biopsy in gynecological malignancies.
"Liquid biopsy": application in three major malignant tumors of gynecology
The "liquid biopsy" technology is a technology that has been developed in recent years. It was originally used for screening and testing of gastrointestinal and breast tumors. With the development of genetic testing technology, it is increasingly used in ovarian cancer, cervical cancer, and endometrial cancer.
ctDNA and ovarian cancer:
Liquid biopsy techniques are most commonly used in ovarian tumors. It can be used for early diagnosis of ovarian cancer, evaluation of surgical results, and prognosis.
Studies have shown that the specificity of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) detection in ovarian malignancies can reach 85% to 90%, which adds a means and method for screening and detection of ovarian cancer.
In addition, abnormal methylation of DNA can occur in the early stage of asymptomatic ovarian cancer, which can indicate the occurrence of ovarian cancer before imaging.
ctDNA and cervical cancer:
Cervical cancer is closely related to HPV infection, but the positive rate of serum HPV DNA in patients with cervical cancer is particularly low, which is obviously unrealistic.
The MYDNA1 gene is most prominent in plasma or serum of patients with cervical cancer, which is very helpful for guiding cervical cancer screening, diagnosis and prognosis.
Medical Nitrile Gloves,Nitrile Gloves Medium,Aql2.5 Industrial Gloves,Disposable Medical Nitrile Gloves
Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshimedical.com